Hepatic Artery Infusion of Floxuridine in Combination With Systemic Chemotherapy for Pancreatic Cancer Liver Metastasis: A Propensity Score-Matched Analysis in Two Centers

作者：Changli Peng, Bin Xu, Juxiong Xiao, Chunhui Zhou, Xiaodong Li, Hongbing Shi, Weiguang Qiang, Tianming Wang, Jiemin Zhao, Fei Liu, Gang Li, Haiping Li, Changyong Chen, Liangrong Shi · 发表于：Frontiers in Oncology · 年份：2021 · DOI：10.3389/fonc.2021.652426 · 被引用次数：12 · 研究领域：Hepatocellular Carcinoma Treatment and Prognosis、Pancreatic and Hepatic Oncology Research、Organ Transplantation Techniques and Outcomes

Aim To evaluate the efficacy of hepatic artery infusion (HAI) of floxuridine (FUDR) in combination with systemic chemotherapy in patients with pancreatic cancer liver metastases (PCLM). Patients and Methods We retrospectively collected clinical data of 347 patients with PCLM who underwent first-line chemotherapy at two Chinese centers between 2012 and 2019. Propensity score matching between patients with and without HAI was performed to compensate for differences in baseline characteristics. Objective response rate (ORR) and overall survival (OS) between groups were compared. HAI pump functionality was recorded. Results Data of 258 patients (62 patients with HAI and 196 patients without HAI) were used for matching. After 1:1 ratio matching, 62 patients per group were included. The intrahepatic ORR was 66.1% in the HAI group and 22.6% in the non-HAI group ( P < 0.001), and the extrahepatic ORR was 25.0 versus 28.9% ( P = 0.679). The median OS was significantly longer in HAI group (14.0 versus 10.8 months, P = 0.001). Multivariance COX regression showed HAI led to a decrease in hazard ratio for death by 61.8% (HR = 0.382; 95% CI: 0.252–0.578; P < 0.001). Subgroup analysis revealed that patients without EHM, with higher intrahepatic tumor burden and with synchronous liver metastasis benefited more from HAI. Dysfunction of HAI pump occurred in 5.7% of patients during the period of follow-up. Conclusions In patients with PCLM, first-line treatment with HAI FUDR plus ...