MicroRNA-370 carried by M2 macrophage-derived exosomes alleviates asthma progression through inhibiting the FGF1/MAPK/STAT1 axis

作者：Chunlu Li, Chengsi Deng, Tingting Zhou, Jiapeng Hu, Bing Dai, Fei Yi, Na Tian, Lijun Jiang, Xiang Da Dong, Qingfeng Zhu, Siyi Zhang, Hongyan Cui, Liu Cao, Yunxiao Shang · 发表于：International Journal of Biological Sciences · 年份：2021 · DOI：10.7150/ijbs.59715 · 被引用次数：62 · 研究领域：Extracellular vesicles in disease、MicroRNA in disease regulation、IL-33, ST2, and ILC Pathways

). Downregulation of miR-370 by Lv-miR-370 inhibitor or overexpression of FGF1 by Lv-FGF1 blocked the protective roles of M2Φ-Exos in asthma-like mouse and cell models. M2Φ-Exos were found to inactivate the MAPK signaling pathway, which was recovered by miR-370 inhibition or FGF1 overexpression. Collectively, we conclude that M2Φ-Exos carry miR-370 to alleviate asthma progression through downregulating FGF1 expression and the MAPK/STAT1 signaling pathway. Our study may offer a novel insight into asthma treatment.