Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2-Hydroxypyrazolo[1,5-a]pyridine Scaffold: SAR of the Biphenyl Moiety

作者：Stefano Sainas, Marta Giorgis, Paola Circosta, Valentina Gaidano, Davide Bonanni, Agnese Chiara Pippione, Renzo Bagnati, Alice Passoni, Yaqi Qiu, Carina F. Cojocaru, Barbara Canepa, Alessandro Bona, Barbara Rolando, Mariia Mishina, Cristina Ramondetti, Barbara Buccinnà, Marco Piccinini, Mohammad Houshmand, Alessandro Cignetti, Enrico Giraudo, Salam Al‐Karadaghi, Donatella Boschi, Giuseppe Saglio, Marco L. Lolli · 发表于：Journal of Medicinal Chemistry · 年份：2021 · DOI：10.1021/acs.jmedchem.0c01549 · 被引用次数：32 · 研究领域：Biochemical and Molecular Research、HIV/AIDS drug development and treatment、Cancer therapeutics and mechanisms

(Jurkat) > 100 μM).