[ Chaihu Guizhi decoction produces antidepressant-like effects via sirt1-p53 signaling pathway].

作者：Xiaoyin Ge, Fuqian Guo, Jun Fan, Bud‐Gen Chen, Lingling Yu, Jing Ren, Ji Li, Chenglin Lu, Jia‐Wen Mo, Shengli Li, Li‐Lian Yuan, Haoyue Hu, Y Liu, Xiaoju Zhou, Jiahui Cui, Zhenxiang Zhu, Xiaomin Cao · 发表于：PubMed · 年份：2021 · DOI：10.12122/j.issn.1673-4254.2021.03.12 · 被引用次数：8 · 研究领域：Tryptophan and brain disorders、Sirtuins and Resveratrol in Medicine、Medicinal Plants and Bioactive Compounds

OBJECTIVE: decoction (CGD). OBJECTIVE: Chaihu Guizhi decoction at the daily dose of 17 g/kg and solvent vehicle were administered by gavage in 12 and 14 male C57BL/6J mice for 7 consecutive days, respectively. Forced swimming test (FST), elevated plus maze (EPM) test, open field test (OFT) and novelty-suppressed feeding test (NSF) were performed to assess the depression- and anxiety-like behaviors and motor ability of the mice. We further used chronic social defeat stress (CSDS) and social interaction test to evaluate the antidepressant-like effects of CGD in comparison with the solvent vehicle. Western blotting and RT-qPCR were performed to detect the expressions of sirt1, p53, acetylated p53, and the neuron plasticity-related genes including synapsin I (Syn1), Rab4B, SNAP25 and tubulin beta4b in the hippocampus of the mice. OBJECTIVE: =0.864) between the two groups. OBJECTIVE: CGD produces antidepressant-like effects in mice possibly through the sirt1-p53 signaling pathway and synaptic plasticity.