Directing-Group-Assisted Markovnikov-Selective Hydrothiolation of Styrenes with Thiols by Photoredox/Cobalt Catalysis

作者：Qian Xiao, Hong Zhang, Jing‐Hong Li, Jing‐Xin Jian, Qing‐Xiao Tong, Jian‐Ji Zhong · 发表于：Organic Letters · 年份：2021 · DOI：10.1021/acs.orglett.1c00999 · 被引用次数：50 · 研究领域：Sulfur-Based Synthesis Techniques、Radical Photochemical Reactions、Cyberloafing and Workplace Behavior

In contrast with the well-developed radical thiol-ene reaction to access anti-Markovnikov-type products, the research on the catalytic Markovnikov-selective hydrothiolation of alkenes is very restricted. Because of the catalyst poisoning of metal catalysts by organosulfur compounds, limited examples of transition-metal-catalyzed thiol-ene reactions have been reported. However, in this work, a directing-group-assisted hydrothiolation of styrenes with thiols by photoredox/cobalt catalysis is found to proceed smoothly to afford Markovnikov-type sulfides with excellent regioselectivity.