Intracerebral Transplantation of Neural Stem Cells Restores Manganese-Induced Cognitive Deficits in Mice

作者：Huijuan Shu, Zhongxin Guo, Xiangren Chen, Shuya Qi, Xinxin Xiong, Shuang Xia, Qingyun Huang, Lan Ling, Jiangu Gong, Shaoming Huang, Boning Yang, Guohe Tan · 发表于：Aging and Disease · 年份：2021 · DOI：10.14336/ad.2020.0717 · 被引用次数：14 · 研究领域：Neurogenesis and neuroplasticity mechanisms、Aluminum toxicity and tolerance in plants and animals、Anesthesia and Neurotoxicity Research

in the Mn-exposed mouse brain, implying enhanced neurogenesis in the host brain. We found that NSCs transplanted into either the hippocampal regions or the lateral ventricles significantly improved spatial learning and memory function of the Mn-exposed mice in the Morris water maze. Immunofluorescence analyses indicated that some surviving NSCs differentiated into neurons or glial cells, which may have become functionally integrated into the impaired local circuits, providing a possible cellular basis for the improvement of cognitive function in NSC-transplanted mice. Taken together, our findings confirm the Mn-induced impairment of neurogenesis in the brain and underscore the potential of treating Mn exposure by NSC transplantation, providing a practical therapeutic strategy against this type of neurotoxicity.