Pharmacological Treatment of Osteoporosis in Elderly People: A Systematic Review and Meta-Analysis

作者：Qinyi Wang, Na Ding, Yi-He Dong, Zhangxin Wen, Rong Chen, Shu-Ying Liu, Hong Liu, Zhifeng Sheng, Yangna Ou · 发表于：Gerontology · 年份：2021 · DOI：10.1159/000514449 · 被引用次数：16 · 研究领域：Bone health and osteoporosis research、Vitamin K Research Studies、Bone Metabolism and Diseases

Background: The evidence supporting the use of antiresorptive and anabolic agents for fracture prevention in elderly patients is still inconclusive. Whether it is too late to alter the course of the disease in this age-group has remained uncertain. Objectives: The objective of this study was to determine the efficacy and safety of antiresorptive and anabolic agents in elderly patients. Methods: PubMed, Web of Science, MEDLINE, and the Cochrane Central Register of Controlled Trials were searched for randomized controlled trials (RCTs) and post hoc analyses of RCTs reporting efficacy outcomes or adverse events of antiresorptive and anabolic agents in elderly patients. Statistical heterogeneity was assessed with the Cochran Q χ2 test and I2 statistic. All results were expressed as relative risk (RR) with 95% confidence intervals (CIs). Results: The meta-analysis included 1 RCT and 11 post hoc analyses of data from 10 double-blind placebo-controlled RCTs. Antiresorptive therapy significantly reduced the pooled incidence of vertebral fractures (RR = 0.43; 95% CI = 0.35–0.53; and p &#x3c; 0.001). It was also associated with lower risk of nonvertebral and hip fractures (RR = 0.84; 95% CI = 0.74–0.96; and p = 0...