Carminic acid supplementation protects against fructose-induced kidney injury mainly through suppressing inflammation and oxidative stress via improving Nrf-2 signaling

作者：Qiang Li, Qifei Xu, Jun Tan, Linfeng Hu, Chenxu Ge, Minxuan Xu · 发表于：Aging · 年份：2021 · DOI：10.18632/aging.202794 · 被引用次数：18 · 研究领域：Diet, Metabolism, and Disease、Genomics, phytochemicals, and oxidative stress、Liver Disease Diagnosis and Treatment

analysis demonstrated that Fru led to metabolic disorder, excessive albuminuria and histologic changes in renal tissues, which were effectively reversed by CA supplementation. We confirmed that CA significantly reduced inflammation and oxidative stress in the kidneys of mice through regulating NF-κB and Nrf-2 signaling pathways, eventually alleviating the progression of chronic kidney injury. Taken together, these results identified CA as a potential therapeutic strategy for metabolic stress-induced renal injury through restraining inflammation and oxidative stress via the improvement of Nrf-2 signaling.