The Mechanism of Facultative Intracellular Parasitism of Brucella

作者：Hanwei Jiao, Zhixiong Zhou, Bowen Li, Yu Xiao, Mengjuan Li, Hui Zeng, Xiaoyi Guo, Guojing Gu · 发表于：International Journal of Molecular Sciences · 年份：2021 · DOI：10.3390/ijms22073673 · 被引用次数：100 · 研究领域：Brucella: diagnosis, epidemiology, treatment、Animal Diversity and Health Studies、Burkholderia infections and melioidosis

Brucellosis is a highly prevalent zoonotic disease characterized by abortion and reproductive dysfunction in pregnant animals. Although the mortality rate of Brucellosis is low, it is harmful to human health, and also seriously affects the development of animal husbandry, tourism and international trade. Brucellosis is caused by Brucella, which is a facultative intracellular parasitic bacteria. It mainly forms Brucella-containing vacuoles (BCV) in the host cell to avoid the combination with lysosome (Lys), so as to avoid the elimination of it by the host immune system. Brucella not only has the ability to resist the phagocytic bactericidal effect, but also can make the host cells form a microenvironment which is conducive to its survival, reproduction and replication, and survive in the host cells for a long time, which eventually leads to the formation of chronic persistent infection. Brucella can proliferate and replicate in cells, evade host immune response and induce persistent infection, which are difficult problems in the treatment and prevention of Brucellosis. Therefore, the paper provides a preliminary overview of the facultative intracellular parasitic and immune escape mechanisms of Brucella, which provides a theoretical basis for the later study on the pathogenesis of Brucella.