A trial of preoperative radiotherapy in the management of operable rectal cancer

作者：First Report of an MRC Working Party, W. Duncan, A. N. Smith, Laurence S. Freedman, M R Alderson, S.J. Arnott, N. M. Bleehen, William H. Bond, D. Crowther, Thomas J. Deeley, H L Duthie, Peter W. Dykes, L. PETER FIELDING, G. E. Flatman, John C. Goligher, Peter R. Hawley, L E Hughes, C. A. Joslin, Osama M. Koriech, B C Morson, G.D. Oates, Michael Peckham, M. R. Sandland, P F Schofield, William Slack, Geoffrey Slaney, Jessica A. Smith, John S. Scott, J. M. A. Whitehouse, P. F. M. Wrigley, A York-Mason · 发表于：British journal of surgery · 年份：1982 · DOI：10.1002/bjs.1800690906 · 被引用次数：71 · 研究领域：Colorectal Cancer Surgical Treatments、Colorectal and Anal Carcinomas、Advances in Oncology and Radiotherapy

Abstract In a multicentre study, 824 patients with operable rectal cancer were randomized to receive surgery alone, surgery plus a single fraction of 500 rad (5 Gy) and surgery plus 2000 rad (20 Gy) in 10 equal daily, i.e. multiple, fractions. The ratio of abdominoperineal excision to anterior restorative operations was 3:1. There was no evidence of an increased morbidity or mortality following irradiation. The multiple fraction 2000 rad group had tumours which were significantly smaller than those of the other groups. There was also a reduction in the Dukes' C cases in the multiple fraction group. Neither the tumour size nor the lymph node status was altered in the single fraction group.