The emerging regulatory roles of long non-coding RNAs implicated in cancer metabolism

作者：Yongcan Xu, Mantang Qiu, Minmin Shen, Shunli Dong, Guochao Ye, Xuefei Shi, Ming Sun · 发表于：Molecular Therapy · 年份：2021 · DOI：10.1016/j.ymthe.2021.03.017 · 被引用次数：66 · 研究领域：Cancer-related molecular mechanisms research、RNA modifications and cancer、Cancer, Hypoxia, and Metabolism

Compared to normal cells, cancer cells exhibit specific metabolic characteristics that facilitate the growth and metastasis of cancer. It is now widely appreciated that long non-coding RNAs (lncRNAs) exert extensive regulatory effects on a spectrum of biological processes through diverse mechanisms. In this review, we focus on the rapidly advancing field of lncRNAs and summarize the relationship between the dysregulation of lncRNAs and cancer metabolism, with a particular emphasis on the specific roles of lncRNAs in glycolysis, mitochondrial function, glutamine, and lipid metabolism. These investigations reveal that lncRNAs are a key factor in the complexity of malignant cancer metabolism. Only through understanding the relevance between lncRNAs and cancer metabolic reprogramming can we open a new chapter in the history of carcinogenesis, one that promises to alter the methods of cancer diagnosis and treatment.