Periostin promotes arterial calcification through PPARγ-related glucose metabolism reprogramming

作者：Yi Zhu, Jing-Jing Ji, Xiaodong Wang, Xuejiao Sun, Min Li, Wei Qin, Liqun Ren, Naifeng Liu · 发表于：American Journal of Physiology-Heart and Circulatory Physiology · 年份：2021 · DOI：10.1152/ajpheart.01009.2020 · 被引用次数：41 · 研究领域：Cardiac Fibrosis and Remodeling、Cardiac Valve Diseases and Treatments、Cardiovascular Function and Risk Factors

Periostin caused arterial calcification, overactivated glycolysis, and damaged OXPHOS. PPARγ agonists alleviated periostin-promoted arterial calcification and corrected abnormal glycolysis and unbalanced mitochondrial homeostasis. There exists a relationship between periostin and lactate in patients with CAC.