Experimentelle Untersuchungen zur Wirkung einer chronischen aerogenen Schadgasbelastung des Saugferkels mit Ammoniak unterschiedlicher Konzentrationen

作者：R. Neumann, Gaby Mehlhorn, Ingeborg Buchholz, U Johannsen, Dietrich Schimmel · 发表于：Journal of Veterinary Medicine Series B · 年份：1987 · DOI：10.1111/j.1439-0450.1987.tb00394.x · 被引用次数：9 · 研究领域：Odor and Emission Control Technologies、Indoor Air Quality and Microbial Exposure、Microbial infections and disease research

Summary Experimental studies of effect of chronic aerogenous toxic gas exposure of unweaned piglets with ammonia of various concentrations II. Reaction of cellular and humoral infection defence mechanisms of ammonia exposed unweaned piglets under conditions of experimentalPasteurella multocidainfection with and without thermo‐motor stress In 2 experiments 58 unweaned piglets were exposed to aerogenous NH3stress up to the 42nd or 35th day of life using a gas concentration of 50 ppm; in a 3rd experiment exposure was for 31 days with NH3concentration of 100 ppm. Some of the animals received an i. v. challenge infection withP. multocida(Carter type A) as well as thermo‐motor stress in the form of a swimming test. The results showed that the ammonia in the concentrations used reduced systemic resistance to infection (serum gammaglobulin concentration and nucleolar activity of peripheral lymphocytes) as well as local resistance to infection in the lungs (pulmonary accumulation of aerosol particles, quantitative cytological of the broncho‐alveolar space) of the unweaned piglets. These findings especially indicate a reduced resistance to infection due to environmental ammonia toxicity playing an important role in infectious respiratory diseases of swine. Zusammenfassung In 2 Versuchen wurden 58 Saugferkel von der Geburt bis zum 42. bzw. 35. Lebenstag einer aerogenen NH3‐Belastung bei einer Gaskonzentration von 50ppm sowie in einem 3. Versuch 28 Saugferkel über 31 Lebenstage einer NH3...