Preterm premature rupture of membranes

作者：César Meller, Maria Eugenia Carducci, José M Ceriani Cernadas, Lucas Otaño · 发表于：Archivos Argentinos de Pediatria · 年份：2018 · DOI：10.5546/aap.2018.eng.e575 · 被引用次数：46 · 研究领域：Bone fractures and treatments

Preterm premature rupture of membranes occurs in around 3% of pregnancies, and several aspects related to its management are still controversial. The objective of this update is to provide a detailed review of strategies aimed at reducing morbidity and mortality associated with this maternal condition. We will discuss the available evidence regarding the maternal use of antibiotics, the use of corticosteroids according to gestational age, the use of magnesium sulphate for fetal neuroprotection, the use of tocolytic agents, and the best moment for and route of delivery. This review also covers the effects of prolonged preterm premature rupture of membranes, infant morbidity and mortality in the short and long term, the harmful effects of antibiotics after delivery, including the effects on neurodevelopment and the presence of longterm chronic diseases.