RIP3 mediates TCN-induced necroptosis through activating mitochondrial metabolism and ROS production in chemotherapy-resistant cancers.

作者：Xu Zhao, Jing Quan, Yue Tan, Ying Liu, Chaoliang Liao, Zhenzhen Li, Weihua Liao, Ji‐Kai Liu, Ya Cao, Xiangjian Luo · 发表于：PubMed · 年份：2021 · 被引用次数：33 · 研究领域：Mitochondrial Function and Pathology、Cancer, Hypoxia, and Metabolism、ATP Synthase and ATPases Research

to promote mitochondria energy metabolism and ROS production. RIP3 might be involved in sensitizing tumor cells to chemotherapy induced by TCN. Therefore, activating RIP3 to initiate necroptosis contributes to the bioactivity of TCN. Moreover, TCN could be exploited for therapeutic gain through up-regulating RIP3 to sensitize cancer chemotherapy.