A towering genome: Experimentally validated adaptations to high blood pressure and extreme stature in the giraffe

作者：Chang Liu, Jianbo Gao, Xinxin Cui, Zhipeng Li, Lei Chen, Yuan Yuan, Yaolei Zhang, Liangwei Mei, Lan Zhao, Dan Cai, Mingliang Hu, Botong Zhou, Zihe Li, Tao Qin, Huazhe Si, Guangyu Li, Zeshan Lin, Yicheng Xu, Chenglong Zhu, Yuan Yin, Chenzhou Zhang, Wenjie Xu, Qingjie Li, Kun Wang, M. Thomas P. Gilbert, Rasmus Heller, Wen Wang, Jinghui Huang, Qiang Qiu · 发表于：Science Advances · 年份：2021 · DOI：10.1126/sciadv.abe9459 · 被引用次数：85 · 研究领域：Physiological and biochemical adaptations、Genetic Mapping and Diversity in Plants and Animals、Adipose Tissue and Metabolism

show exceptional hypertension resistance and higher bone mineral density, both of which are tightly connected with giraffe adaptations to high stature. Our results facilitate a deeper understanding of the molecular mechanism underpinning distinct giraffe traits, and may provide insights into the study of hypertension in humans.