Borylation of Unactivated C(sp 3 )–H Bonds with Bromide as a Traceless Directing Group

作者：Ge Zhang, Mengyao Li, Wen-Bo Ye, Zhi‐Tao He, Chen‐Guo Feng, Guo‐Qiang Lin · 发表于：Organic Letters · 年份：2021 · DOI：10.1021/acs.orglett.1c00617 · 被引用次数：27 · 研究领域：Catalytic C–H Functionalization Methods、Catalytic Cross-Coupling Reactions、Synthesis and Catalytic Reactions

A palladium-catalyzed alkyl C-H borylation with bromide as a traceless directing group is described, providing a convenient approach to access alkyl boronates bearing a β-all-carbon quaternary stereocenter. The protocol features a broad substrate scope, excellent site selectivity, and good functional group tolerance.