FGF19/SOCE/NFATc2 signaling circuit facilitates the self-renewal of liver cancer stem cells

作者：Jingchun Wang, Huakan Zhao, Lu Zheng, Yu Zhou, Lei Wu, Yanquan Xu, Xiao Zhang, Guifang Yan, Halei Sheng, Rong Xin, Lu Jiang, Juan Lei, Jian Gang Zhang, Yu Chen, Jin Peng, Qian Chen, Shuai Yang, Kun Yu, Dingshan Li, Qichao Xie, Yongsheng Li · 发表于：Theranostics · 年份：2021 · DOI：10.7150/thno.56369 · 被引用次数：49 · 研究领域：Fibroblast Growth Factor Research、Kruppel-like factors research、Wnt/β-catenin signaling in development and cancer

activating SOCE/NFATc2 pathway; in turn, NFATc2 transcriptionally activates FGF19 expression. Targeting this signaling circuit represents a potential strategy for improving the therapeutic efficacy of HCC.