Exosome-mediated delivery of an anti-angiogenic peptide inhibits pathological retinal angiogenesis

作者：Xue Dong, Lei Yi, Zeyang Yu, Tian Wang, Yi Liu, Gang Han, Xiaodan Zhang, Yiming Li, Yinting Song, Heping Xu, Mei Du, HaiFang Yin, Xiaohong Wang, Hua Yan · 发表于：Theranostics · 年份：2021 · DOI：10.7150/thno.54755 · 被引用次数：135 · 研究领域：Extracellular vesicles in disease、RNA Interference and Gene Delivery、MicroRNA in disease regulation

We used EXOs as a carrier for intraocular delivery of KV11. We showed that KV11 itself has an anti-angiogenic effect through retro-orbital injection, but that this effect was greatly enhanced when delivered with EXOs. Thus, this system has the potential to treat proliferative retinopathy via retro-orbital injection which is a less invasive manner compared with intravitreal injection.