A literature survey of all volatiles from healthy human breath and bodily fluids: the human volatilome

作者：Natalia Drabińska, Cheryl Flynn, Norman Ratcliffe, Ilaria Belluomo, Antonis Myridakis, Oliver Gould, Matteo Fois, Amy Smart, Terry L. Devine, Ben de Lacy Costello · 发表于：Journal of Breath Research · 年份：2021 · DOI：10.1088/1752-7163/abf1d0 · 被引用次数：292 · 研究领域：Advanced Chemical Sensor Technologies、Olfactory and Sensory Function Studies、Insect Pheromone Research and Control

This paper comprises an updated version of the 2014 review which reported 1846 volatile organic compounds (VOCs) identified from healthy humans. In total over 900 additional VOCs have been reported since the 2014 review and the VOCs from semen have been added. The numbers of VOCs found in breath and the other bodily fluids are: blood 379, breath 1488, faeces 443, milk 290, saliva 549, semen 196, skin 623 and urine 444. Compounds were assigned CAS registry numbers and named according to a common convention where possible. The compounds have been included in a single table with the source reference(s) for each VOC, an update on our 2014 paper. VOCs have also been grouped into tables according to their chemical class or functionality to permit easy comparison. Careful use of the database is needed, as a number of the identified VOCs only have level 2-putative assignment, and only a small fraction of the reported VOCs have been validated by standards. Some clear differences are observed, for instance, a lack of esters in urine with a high number in faeces and breath. However, the lack of compounds from matrices such a semen and milk compared to breath for example could be due to the techniques used or reflect the intensity of effort e.g. there are few publications on VOCs from milk and semen compared to a large number for breath. The large number of volatiles reported from skin is partly due to the methodologies used, e.g. by collecting skin sebum (with dissolved VOCs and semi VO...