Pd-Catalyzed Assembly of Fluoren-9-ones by Merging of C–H Activation and Difluorocarbene Transfer

作者：Xiaobing Liu, Heyun Sheng, Yao Zhou, Qiuling Song · 发表于：Organic Letters · 年份：2021 · DOI：10.1021/acs.orglett.1c00467 · 被引用次数：61 · 研究领域：Fluorine in Organic Chemistry、Catalytic C–H Functionalization Methods、Cyclopropane Reaction Mechanisms

We disclose a novel Pd-catalyzed assembly of fluoren-9-ones by merging of C–H activation and difluorocarbene transfer. ClCF 2 COONa served as a difluorocarbene precursor to be harnessed as a carbonyl source in this transformation. The current protocol enables us to afford fluoren-9-ones in high yields with excellent functional group compatibility, which also represents the first example of using difluorocarbene as a coupling partner in transition-metal-catalyzed C–H activation.