A tumor-suppressive circular RNA mediates uncanonical integrin degradation by the proteasome in liver cancer

作者：Liang Shi, Boqiang Liu, Dandan Shen, Peijian Yan, Yanan Zhang, Yuanshi Tian, Lidan Hou, Guangyi Jiang, Yinxin Zhu, Yuelong Liang, Xiao Liang, Bo Shen, Hong Yu, Yan Zhang, Yifan Wang, Xing Guo, Xiujun Cai · 发表于：Science Advances · 年份：2021 · DOI：10.1126/sciadv.abe5043 · 被引用次数：109 · 研究领域：Circular RNAs in diseases、interferon and immune responses、RNA Research and Splicing

integrin). Mass spectrometry and biochemical evidence demonstrate that circPABPC1 directly links ITGB1 to the 26S proteasome for degradation in a ubiquitination-independent manner. Our data have revealed an uncanonical route for integrin turnover and a previously unidentified mode of action for circRNAs in HCC that can be harnessed for anticancer treatment.