Distinct kinetics of immunoglobulin isotypes reveal early diagnosis and disease severity of COVID‐19: A 6‐month follow‐up

作者：Siyang Yu, Jianghong An, Xuejiao Liao, Haiyan Wang, Fen Ma, Dapeng Li, Aimin Li, Weilong Liu, Siwei Zhang, Mingfeng Liao, Lei Liu, Juanjuan Zhao, Shaojun Xing, Lanlan Wei, Zheng Zhang · 发表于：Clinical and Translational Medicine · 年份：2021 · DOI：10.1002/ctm2.342 · 被引用次数：10 · 研究领域：SARS-CoV-2 and COVID-19 Research、COVID-19 Clinical Research Studies、COVID-19 epidemiological studies

This study provides a comprehensive dynamic analysis of different antibody isotypes against SARS-CoV-2 and their relation to disease severity or early COVID-19 diagnosis in a large patient cohort over a 6-month follow-up period, which will benefit the early diagnosis and assessment of disease severity for COVID-19. Despite ongoing studies on the kinetics of SARS-CoV-2-specific antibodies,1-5 it is still insufficient for the comprehensive analysis of long-term kinetics and durability of viral-specific antibody isotypes and their relation to disease severity or early COVID-19 diagnosis. In this study, we evaluated the dynamics of SARS-CoV-2-specific immunoglobulins (A, G, and M) and its correlation to viral clearance and disease severity in a large cohort of COVID-19 patients for 6 months. Besides, IgA and IgG in saliva and bronchoalveolar lavage fluid (BALF) were also assessed for the diagnosis of COVID-19. A total of 506 patients diagnosed with COVID-19 basing on the World Health Organization's interim guidance (WHO 2020) were followed up for 6 months at the Shenzhen Third People's Hospital in this study. All patients were classified into asymptomatic, mild, moderate, and severe groups by the disease severity of COVID-19 (Table 1). IgA, IgG, and IgM against the SARS-CoV-2 spike protein receptor-binding domain (RBD) was measured (Chemiluminescence immunoassay kit, Beijing Wantai Biotech) in 2628 of plasma from 44 asymptomatic carriers, 29 mild, 340 moderate, and 93 severe pati...