Rates of Incidental Findings in Brain Magnetic Resonance Imaging in Children

作者：Yi Li, Wesley K. Thompson, Chase Reuter, Ryan M. Nillo, Terry L. Jernigan, Anders M. Dale, Leo P. Sugrue, Julian Brown, Robert F. Dougherty, Andreas M. Rauschecker, Jeffrey D. Rudie, Deanna M. Barch, Vince D. Calhoun, Donald J. Hagler, Sean N. Hatton, Jody Tanabe, Andrew T. Marshall, Kenneth J. Sher, Steven G. Heeringa, Robert Hermosillo, Marie T. Banich, Lindsay M. Squeglia, James M. Bjork, Robert A. Zucker, Michael C. Neale, Megan M. Herting, Chandni Sheth, Rebekah S. Huber, Gloria Reeves, John M. Hettema, Katia Delrahim Howlett, Christine Cloak, Arielle Baskin–Sommers, Kristina M. Rapuano, Raúl González, Nicole R. Karcher, Angela R. Laird, Fiona C. Baker, Regina Smith James, Elizabeth R. Sowell, Anthony Steven Dick, Samuel W. Hawes, Matthew T. Sutherland, Kara Bagot, Jerzy Bodurka, Florence J. Breslin, Amanda Sheffield Morris, Martin P. Paulus, Kevin M. Gray, Elizabeth A. Hoffman, Susan R.B. Weiss, Nishadi Rajapakse, Meyer D. Glantz, Bonnie J. Nagel, Sarah Feldstein Ewing, Aimée Goldstone, Adolf Pfefferbaum, Devin Prouty, Monica D. Rosenberg, Susan Y. Bookheimer, Susan F. Tapert, M. Alejandra Infante, Joanna Jacobus, Jay N. Giedd, Paul D. Shilling, Natasha E. Wade, Kristina A. Uban, Frank Haist, Charles J. Heyser, Clare E. Palmer, Joshua Kuperman, John K. Hewitt, Linda B. Cottler, Amal Isaiah, Linda Chang, Sarah Edwards, Thomas Ernst, Mary M. Heitzeg, Leon I. Puttler, Chandra Sripada, William G. Iacono, Mónica Luciana, Duncan B. Clark, Beatríz Luna, Claudiu Schirda, John J. Foxe, Edward G. Freedman, Michael J. Mason, Erin McGlade, Perry F. Renshaw, Deborah Yurgelun‐Todd, Matthew D. Albaugh, Nicholas Allgaier, Bader Chaarani, Alexandra Potter, Masha Y. Ivanova, Krista M. Lisdahl, K. Elizabeth, Hermine H. Maes, Ryan Bogdan, Andrey P. Anokhin, Nico U.F. Dosenbach, Paul E.A. Glaser, Andrew C. Heath, B. J. Casey, Dylan G. Gee, Hugh Garavan, Gaya Dowling, Sandra A. Brown · 发表于：JAMA Neurology · 年份：2021 · DOI：10.1001/jamaneurol.2021.0306 · 被引用次数：67 · 研究领域：Fetal and Pediatric Neurological Disorders、Epilepsy research and treatment、Traumatic Brain Injury Research

Importance: Incidental findings (IFs) are unexpected abnormalities discovered during imaging and can range from normal anatomic variants to findings requiring urgent medical intervention. In the case of brain magnetic resonance imaging (MRI), reliable data about the prevalence and significance of IFs in the general population are limited, making it difficult to anticipate, communicate, and manage these findings. Objectives: To determine the overall prevalence of IFs in brain MRI in the nonclinical pediatric population as well as the rates of specific findings and findings for which clinical referral is recommended. Design, Setting, and Participants: This cohort study was based on the April 2019 release of baseline data from 11 810 children aged 9 to 10 years who were enrolled and completed baseline neuroimaging in the Adolescent Brain Cognitive Development (ABCD) study, the largest US population-based longitudinal observational study of brain development and child health, between September 1, 2016, and November 15, 2018. Participants were enrolled at 21 sites across the US designed to mirror the demographic characteristics of the US population. Baseline structural MRIs were centrally reviewed for IFs by board-certified neuroradiologists and findings were described and categorized (category 1, no abnormal findings; 2, no referral recommended; 3; consider referral; and 4, consider immediate referral). Children were enrolled through a broad school-based recruitment process in wh...