Palladium-Catalyzed Linear Hydrothiocarbonylation of Unactivated Terminal Alkenes: Synthesis of Aliphatic Thioesters

作者：Wangzhi Yu, Jian Han, Dongmei Fang, Min Wang, Jian Liao · 发表于：Organic Letters · 年份：2021 · DOI：10.1021/acs.orglett.1c00406 · 被引用次数：24 · 研究领域：Sulfur-Based Synthesis Techniques、Catalytic C–H Functionalization Methods、Chemical Synthesis and Reactions

A Pd-catalyzed hydrothiocarbonylation of unactivated terminal alkenes is presented. According to this protocol, aliphatic thioesters were synthesized with exclusive linear selectivity under mild reaction conditions. Good to excellent yields (up to 91% yield), broad substrate scope, broad functional group tolerance, and utility of the method demonstrated the advantages of this protocol.