Estimated SARS-CoV-2 Seroprevalence Among Persons Aged <18 Years — Mississippi, May–September 2020

作者：Charlotte V. Hobbs, Jan Drobeniuc, Theresa Kittle, John M. Williams, Paul Byers, Panayampalli S. Satheshkumar, Kengo Inagaki, Meagan Stephenson, Sara Kim, Manish Patel, Brendan Flannery, CDC COVID-19 Response Team, CDC COVID-19 Response Team, Bailey Alston, Shanna Bolcen, Darbi Boulay, Peter Browning, Li Cronin, Ebenezer David, Tonya Hayden, Li Han, Travis Lim, Panagiotis Maniatis, Palak Patel, Mathew Pauly, Amanda Poe, Lili Punkova, Vera Semenova, Evelene Steward‐Clark, Alexandra Tejada, Briana Zellner · 发表于：MMWR Morbidity and Mortality Weekly Report · 年份：2021 · DOI：10.15585/mmwr.mm7009a4 · 被引用次数：52 · 研究领域：SARS-CoV-2 and COVID-19 Research、SARS-CoV-2 detection and testing、COVID-19 Clinical Research Studies

As of March 1, 2021, persons aged <18 years accounted for approximately 11% of 28.4 million reported COVID-19 cases in the United States*; however, data on pediatric infections with SARS-CoV-2, the virus that causes COVID-19, are limited (1). Surveys of SARS-CoV-2 antibody seroprevalence suggest that cumulative incidence of infection is much higher than that ascertained by reported COVID-19 cases (2,3). Evidence of previous SARS-CoV-2 infections among young persons in Mississippi was assessed by testing for antibodies to SARS-CoV-2 on a convenience sample of residual serum specimens collected for routine testing by an academic medical center laboratory during May 17-September 19, 2020. Seroprevalence by calendar month was standardized to the state population by race/ethnicity; cumulative numbers of infections were estimated by extrapolating seroprevalence to all persons aged <18 years in Mississippi. Serum specimens from 1,603 persons were tested; 175 (10.9%) were positive for SARS-CoV-2 antibodies. Among 1,579 (98.5%) specimens for which the race/ethnicity of the person tested was known, specimens from 16 (23.2%) of 69 Hispanic persons, 117 (13.0%) of 901 non-Hispanic Black persons, and 30 (5.3%) of 565 non-Hispanic White persons tested positive. Populationweighted seroprevalence estimates among persons aged <18 years increased from 2.5% in May to 16.3% in September 2020. Based on these estimates, 113,842 (95% confidence interval [CI] = 90,096-153,652) persons aged <18 years...