Interplay between cyclooxygenase‑2 and microRNAs in cancer (Review)

作者：Zexiong Gong, Weiguo Huang, Baiyun Wang, Na Liang, Songkai Long, Wanjun Li, Qier Zhou · 发表于：Molecular Medicine Reports · 年份：2021 · DOI：10.3892/mmr.2021.11986 · 被引用次数：16 · 研究领域：Inflammatory mediators and NSAID effects、MicroRNA in disease regulation、Cancer, Stress, Anesthesia, and Immune Response

Tumor‑associated inflammation and aberrantly expressed biomarkers have been demonstrated to play crucial roles in the cancer microenvironment. Cyclooxygenase‑2 (COX‑2), a prominent inflammatory factor, is highly expressed in tumor cells and contributes to tumor growth, recurrence and metastasis. Overexpression of COX‑2 may occur at both transcriptional and post‑transcriptional levels. Thus, an improved understanding of the regulatory mechanisms of COX‑2 can facilitate the development of novel antitumor therapies. MicroRNAs (miRNAs) are a group of small non‑coding RNAs that act as translation repressors of target mRNAs, and play vital roles in regulating cancer development and progression. The present review discusses the association between miRNAs and COX‑2 expression in different types of cancer. Understanding the regulatory role of miRNAs in COX‑2 post‑transcription can provide novel insight for suppressing COX‑2 expression via gene silencing mechanisms, which offer new perspectives and future directions for the development of novel COX‑2 selective inhibitors based on miRNAs.