Tea consumption and long-term risk of type 2 diabetes and diabetic complications: a cohort study of 0.5 million Chinese adults

作者：Jia Nie, Canqing Yu, Yu Guo, Pei Pei, Lu Chen, Yuanjie Pang, Huaidong Du, Ling Yang, Yiping Chen, Shichun Yan, Junshi Chen, Zhengming Chen, Jun Lv, Liming Li · 发表于：American Journal of Clinical Nutrition · 年份：2021 · DOI：10.1093/ajcn/nqab006 · 被引用次数：78 · 研究领域：Tea Polyphenols and Effects、Nutritional Studies and Diet、Heavy Metals in Plants

BACKGROUND: Evidence from epidemiological studies remains inconsistent or limited about the associations of tea consumption with incident diabetes and risk of diabetic complications and death among patients with diabetes. OBJECTIVES: We aimed to investigate the associations of tea consumption with long-term risk of developing type 2 diabetes (T2D) and risks of diabetic complications and death among patients with diabetes. METHODS: This study included 482,425 diabetes-free participants and 30,300 patients with diabetes aged 30-79 y at study enrollment from the China Kadoorie Biobank. Tea consumption information was collected at baseline by interviewer-administered questionnaires. Incidences of diabetes, diabetic complications, and death were identified by linkages to the National Health Insurance system, disease registries, and death registries. Cox proportional hazard regression models were used to estimate HRs and 95% CIs. RESULTS: The mean ± SD age of participants free of diabetes was 51.2 ± 10.5 y and 41% were male. The mean ± SD age of patients with diabetes was 58.2 ± 9.6 y and 39% were male. Of all daily tea consumers, 85.8% preferred green tea. In the diabetes-free population, 17,434 participants developed incident T2D during 11.1 y of follow-up. Compared with participants who never consumed tea in the past year, the HR (95% CI) of T2D for daily consumers was 0.92 (0.88, 0.97). In patients with diabetes, we identified 6572 deaths, 12,677 diabetic macrovascular cases, a...