Association Between Preterm-Birth Phenotypes and Differential Morbidity, Growth, and Neurodevelopment at Age 2 Years

作者：José Villar, María Clara Restrepo–Méndez, Rose McGready, Fernando C. Barros, César G. Victora, Shama Munim, Aris T. Papageorghiou, Roseline Ochieng, Rachel Craik, Hellen C. Barsosio, James A. Berkley, Maria Carvalho, Michelle Fernandes, Leila Cheikh Ismail, Ann Lambert, Shane A. Norris, Eric O. Ohuma, Alan Stein, Chrystelle O.O. Tshivuila-Matala, Krina T. Zondervan, Adele Winsey, François Nosten, Ricardo Uauy, Zulfiqar A Bhutta, Stephen Kennedy · 发表于：Archives of Pediatrics and Adolescent Medicine · 年份：2021 · DOI：10.1001/jamapediatrics.2020.6087 · 被引用次数：61 · 研究领域：Preterm Birth and Chorioamnionitis、Infant Development and Preterm Care、Pregnancy and preeclampsia studies

Importance: The etiologic complexities of preterm birth remain inadequately understood, which may impede the development of better preventative and treatment measures. Objective: To examine the association between specific preterm-birth phenotypes and clinical, growth, and neurodevelopmental differences among preterm newborns compared with term newborns up to age 2 years. Design, Setting, and Participants: The INTERBIO-21st study included a cohort of preterm and term newborn singletons enrolled between March 2012 and June 2018 from maternity hospitals in 6 countries worldwide who were followed up from birth to age 2 years. All pregnancies were dated by ultrasonography. Data were analyzed from November 2019 to October 2020. Exposures/Interventions: Preterm-birth phenotypes. Main Outcomes and Measures: Infant size, health, nutrition, and World Health Organization motor development milestones assessed at ages 1 and 2 years; neurodevelopment evaluated at age 2 years using the INTERGROWTH-21st Neurodevelopment Assessment (INTER-NDA) tool. Results: A total of 6529 infants (3312 boys [50.7%]) were included in the analysis. Of those, 1381 were preterm births (mean [SD] gestational age at birth, 34.4 [0.1] weeks; 5148 were term births (mean [SD] gestational age at birth, 39.4 [0] weeks). Among 1381 preterm newborns, 8 phenotypes were identified: no main maternal, fetal, or placental condition detected (485 infants [35.1%]); infections (289 infants [20.9%]); preeclampsia (162 infants [...