The different phenotypes of COPD

作者：Ahmed Yousuf, Hamish J. C. McAuley, Omer Elneima, Christopher Edward Brightling · 发表于：British Medical Bulletin · 年份：2021 · DOI：10.1093/bmb/ldaa043 · 被引用次数：36 · 研究领域：Chronic Obstructive Pulmonary Disease (COPD) Research、Asthma and respiratory diseases、Delphi Technique in Research

BACKGROUND: Chronic obstructive pulmonary disease (COPD) is associated with significant morbidity and mortality. To improve the health status and reduce symptom burden, it is important to identify a group of patients with similar characteristics and prognosis, called clinical phenotypes. Herein we shall review the different phenotypes of COPD. SOURCES OF DATA: Keywords (COPD, phenotype, acute exacerbation) search was conducted in PubMed, Google Scholar. AREAS OF AGREEMENT: Those with raised blood eosinophil counts respond better to steroid therapy at stable state and exacerbation. AREAS OF CONTROVERSY: There is no universally accepted blood eosinophil cut-off value that will indicate favourable response to corticosteroids and potentially for future biologic therapy. GROWING POINTS: There is an urgent need for further therapeutic options for COPD patients with non-eosinophilic inflammation. AREAS TIMELY FOR DEVELOPING RESEARCH: Well-designed COPD trials with identification of phenotypes for more personalization of the treatment of COPD.