Long-lasting analgesia via targeted in situ repression of Na V 1.7 in mice

作者：Ana M. Moreno, Fernando Alemán, Glaucilene Ferreira Catroli, Matthew A. Hunt, Michael Hu, Amir Dailamy, Andrew Pla, Sarah A. Woller, Nathan Palmer, Udit Parekh, Daniella McDonald, Amanda J. Roberts, Vanessa Goodwill, Ian Dryden, Robert F. Hevner, Lauriane Delay, Gilson Gonçalves dos Santos, Tony L. Yaksh, Prashant Mali · 发表于：Science Translational Medicine · 年份：2021 · DOI：10.1126/scitranslmed.aay9056 · 被引用次数：128 · 研究领域：Pain Mechanisms and Treatments、Neuroscience and Neuropharmacology Research、Ion channel regulation and function

In situ genome targeting of Na V 1.7 via CRISPRs and zinc fingers enables genomically scarless, durable, and nonaddictive management of pain.