Association between SARS-CoV-2 and exposure risks in health care workers and university employees – a cross-sectional study

作者：D. R. Nygren, Jonas Norén, Yang De Marinis, Anna Holmberg, Carl‐Johan Fraenkel, Magnus Rasmussen · 发表于：Scandinavian Journal of Infectious Diseases · 年份：2021 · DOI：10.1080/23744235.2021.1892819 · 被引用次数：27 · 研究领域：Infection Control and Ventilation、SARS-CoV-2 and COVID-19 Research、COVID-19 epidemiological studies

Background In health care workers SARS-CoV-2 has been shown to be an occupational health risk, often associated with transmission between health care workers. Yet, insufficient information on transmission dynamics has been presented to elucidate the precise risk factors for contracting SARS-CoV-2 in this group.Methods In this cross-sectional study, we investigated association between questionnaire answers on potential exposure situations and SARS-CoV-2-positivity. Health care workers with and without COVID-19-patient contact at nine units at Skåne University Hospitals in Malmö and Lund, Sweden and university employees from Lund University, Sweden were enrolled. To limit impact of health care worker to health care worker transmission, units with known outbreaks were excluded. A SARS-CoV-2-positive case was defined by a previous positive PCR or anti-SARS-CoV-2 IgG in the ZetaGene COVID-19 Antibody Test.Results SARS-CoV-2-positivity was detected in 11/51 (22%) health care workers in COVID-19-units, 10/220 (5%) in non-COVID-19-units and 11/192 (6%) University employees (p = .001, Fischer’s exact). In health care workers, SARS-CoV-2-positivity was associated with work in a designated COVID-19-unit (OR 5.7 (95CI 2.1–16)) and caring for COVID-19-patients during the majority of shifts (OR 5.4 (95CI 2.0–15)). In all participants, SARS-CoV-2-positivity was associated with a confirmed COVID-19 case (OR 10 (95CI 2.0–45)) in the household.Conclusion Our study confirmed previous findings o...