Aloe-emodin derived azoles as a new structural type of potential antibacterial agents: design, synthesis, and evaluation of the action on membrane, DNA, and MRSA DNA isomerase

作者：Xinyuan Liang, Narsaiah Battini, Yan‐Fei Sui, Mohammad Fawad Ansari, Linling Gan, Cheng‐He Zhou · 发表于：RSC Medicinal Chemistry · 年份：2021 · DOI：10.1039/d0md00429d · 被引用次数：46 · 研究领域：Phytochemistry and biological activity of medicinal plants、DNA and Nucleic Acid Chemistry、Bioactive Compounds and Antitumor Agents

Tetrazole aloe-emodin 4b displayed potent efficacy against MRSA, and it was found to rapidly permeate the bacterial membrane to intercalate into DNA and form supermolecule with MRSA DNA isomerase (PDB code: 2XCS).