Ultrafast Directional Janus Pt–Mesoporous Silica Nanomotors for Smart Drug Delivery

作者：Paula Díez, Elena Lucena‐Sánchez, Andrea Escudero, Antoni Llopis‐Lorente, Reynaldo Villalonga, Ramón Martínez‐Máñez · 发表于：ACS Nano · 年份：2021 · DOI：10.1021/acsnano.0c08404 · 被引用次数：181 · 研究领域：Micro and Nano Robotics、Electrohydrodynamics and Fluid Dynamics、Molecular Communication and Nanonetworks

Development of bioinspired nanomachines with an efficient propulsion and cargo-towing has attracted much attention in the last years due to their potential biosensing, diagnostics, and therapeutics applications. In this context, self-propelled synthetic nanomotors are promising carriers for intelligent and controlled release of therapeutic payloads. However, the implementation of this technology in real biomedical applications is still facing several challenges. Herein, we report the design, synthesis, and characterization of innovative multifunctional gated platinum-mesoporous silica nanomotors constituted of a propelling element (platinum nanodendrite face), a drug-loaded nanocontainer (mesoporous silica nanoparticle face), and a disulfide-containing oligo(ethylene glycol) chain (S-S-PEG) as a gating system. These Janus-type nanomotors present an ultrafast self-propelled motion due to the catalytic decomposition of low concentrations of hydrogen peroxide. Likewise, nanomotors exhibit a directional movement, which drives the engines toward biological targets, THP-1 cancer cells, as demonstrated using a microchip device that mimics penetration from capillary to postcapillary vessels. This fast and directional displacement facilitates the rapid cellular internalization and the on-demand specific release of a cytotoxic drug into the cytosol, due to the reduction of the disulfide bonds of the capping ensemble by intracellular glutathione levels. In the microchip device and in th...