Association of Intensive vs Standard Blood Pressure Control With Magnetic Resonance Imaging Biomarkers of Alzheimer Disease

作者：Ilya M. Nasrallah, Sarah A. Gaussoin, Raymond Pomponio, Sudipto Dolui, Güray Erus, Clinton B. Wright, Lenore J. Launer, John A. Detre, David A. Wolk, Christos Davatzikos, Jeff D. Williamson, Nicholas M. Pajewski, R. Nick Bryan, Paul K. Whelton, Karen Johnson, Joni Snyder, Diane E. Bild, Denise E. Bonds, Nakela L. Cook, Jeffrey A. Cutler, Lawrence J. Fine, Peter Kaufmann, Paul L. Kimmel, Lenore J. Launer, Claudia S. Moy, William T. Riley, Laurie Ryan, Eser Tolunay, Song Yang, David M. Reboussin, Jeff D. Williamson, Walter T. Ambrosius, William B. Applegate, Greg Evans, Capri G. Foy, Barry I. Freedman, Dalane W. Kitzman, Mary F. Lyles, Nicholas M. Pajewski, Steve Rapp, Scott Rushing, Neel Shah, Kaycee M. Sink, Mara Z. Vitolins, Lynne Wagenknecht, Valerie Wilson, Letitia Perdue, Nancy Woolard, Tim Craven, Katelyn R Garcia, Sarah A. Gaussoin, Laura Lovato, Jill C. Newman, James Lovato, Lingyi Lu, Chris McLouth, Greg Russell, Bobby Amoroso, Patty Davis, Jason Griffin, Darrin Harris, Mark King, Kathy Lane, W. J. Roberson, Debbie Steinberg, Donna Ashford, Phyllis Babcock, Dana Chamberlain, Vickie Christensen, Loretta Cloud, Christy L. Collins, Delilah Cook, Katherine Currie, Debbie Felton, Stacy Harpe, Marjorie Howard, Michelle Lewis, Pamela Nance, Nicole Puccinelli‐Ortega, Laurie Russell, Jennifer Walker, Brenda Craven, Candace Goode, Margie Troxler, Janet Davis, Sarah Hutchens, Anthony A. Killeen, Anna M. Lukkari, Robert Ringer, Brandi Dillard, Norbert Archibeque, Stuart Warren, Mike R. Sather, James Pontzer, Zach Taylor, Elsayed Z. Soliman, Zhu‐Ming Zhang, Yabing Li, Chuck Campbell, Susan Hensley, Julie Hu, Lisa Keasler, Mary Barr, Tonya Taylor, R. Nick Bryan, Christos Davatzikos, Ilya M. Nasrallah, Lisa Desiderio, Mark A. Elliott, Arijitt Borthakur, Harsha Battapady, Güray Erus, Alex Smith, Ze Wang, Jimit Doshi, Jackson T. Wright, Mahboob Rahman, Alan J. Lerner, Carolyn H. Still, Alan Wiggers, Sara Zamanian, Alberta Bee, Renee Dancie, George Thomas, Martin Schreiber, Sankar D. Navaneethan, John Hickner, Michael Lioudis, Michelle Lard, Susan Marczewski, Jennifer Maraschky, Martha Colman, Andrea Aaby, Stacey Payne, Melanie Ramos, Carol Horner, Paul E. Drawz, Pratibha P. Raghavendra, Scott Ober, Ronda Mourad, Muralidhar Pallaki, Peter Russo, Paul Fantauzzo, Lisa Tucker, Bill Schwing, John R. Sedor, Edward Horwitz, Jeffrey R. Schellling, John F. O’Toole, Lisa Humbert, Wendy Tutolo, Suzanne White, Alishea Gay, Walter Clark, Robin Hughes, Mirela Dobre, Monique Williams, Udayan Bhatt, Lee Hebert, Anil Agarwal, Melissa Brown Murphy, Nicole D. Ford, Cynthia Stratton, Jody Baxter, Alicia A. Lykins, Alison McKinley Neal, Leena Hirmath, Kwame Osei, Kyaw Soe, William F. Miser, Colleen Sagrilla, J. Johnston, Amber Anaya, Ashley Mintos, Angel A. Howell, Kelly L. Rogers, Sara Taylor, Donald Ebersbacher, Lucy Long, Beth Bednarchik, Adrian M. Schnall, Jonathan Smith, Lori Peysha, Lisa Leach, Megan Tribout, Carla Harwell, Pinkie Ellington, Mary Ann Banerji, Pranav Ghody, Melissa Vahided Rambaud, Raymond R. Townsend, Debbie L. Cohen, Yonghong Huan, Mark Duckworth, Virginia Ford, Juliet Leshner, Ann Davison, Sarah Vander Veen, Crystal A. Gadegbeku, Avi Gillespie, Anuradha Paranjee, S Amoroso, Zoe Pfeffer, Sally B. Quinn, Jiang He, Jing Chen, Eva Lustigova, Erin Malone, Marie Krousel‐Wood, Richard Deichmann, Patricia Ronney, Susan Muery, Donnalee Trapani, Michael V. Rocco, David C. Goff, Carlos J. Rodríguez, Laura H. Coker, Amret Hawfield, Joseph Yeboah, Lenore Crago, John H. Summerson, Anita Hege, Matt Diamond, Laura Mulloy, Marcela Hodges, Michelle Collins, Charlene Weathers, Heather Anderson, Emily Stone, W. A. Walker, Andrew McWilliams, Michael Dulin, Lindsay Kuhn, Susan Standridge, Lindsay Lowe, Kelly Everett, Kelry Preston, Susan J. Norton, Silena Gaines, Ali A. Rizvi, Andrew W. Sides, Diamond Herbert, Matthew M. Hix, Melanie Whitmire, Brittany Arnold, Philip Hutchinson, Joseph Espiritu, Mark N. Feinglos, Eugene C. Kovalik, Georgianne Gedon-Lipscomb, Kathryn L. Evans, Connie Thacker, Ronna Zimmer, Mary Furst, Maryann Mason, James Powell, Paul Bolin, Junhong Zhang, Mary Pinion, Gail C. Davis, Winifred Bryant, Presley Phelps, Connie Garris-Sutton, Beatrice Atkinson, Gabriele Contreras, Maritza Suarez, Ivonne Hernandez Schulman, Don Koggan, Jackie Vassallo, Gloria Peruyera, Sheri Whittington, Cassandra Bethea, Laura Gilliam, Carolyn Pedley, Geraldine Zurek, Miriam Baird, Charles Herring, Mary Martha Smoak, Julie Williams, Samantha Rogers, Lindsay Gordon, Erin Kennedy, Beverly Belle, Jessica McCorkle-Doomy, Jon Adams, Ramon Lopez, Juris Jamavs, Frederic F. Rahbari-Oskoui, Arlene B. Chapman, Allen Dollar, Olubunmi Williams, Yoosun Han, William E. Haley, Peter M. Fitzpatrick, Joseph L. Blackshear, Brian P. Shapiro, Anna Harrell, Arta Palaj, Katelyn Henderson, Ashley Johnson, Heath Gonzalez, Jermaine Robinson, Leonardo Tamariz, Dhurga Krishnamoorthy, Rody Barakat, Jennifer Denizard, Frank L. Greenway, Ron Monce, Timothy S. Church, Chelsea Hendrick, Aimee Yoches, Leighanne Sones, Markee Baltazar, Priscilla Pemu, Connie Jones, Derrick Akpalu, Alfred K. Cheung, Srinivasan Beddhu, Gordon J. Chelune, Jeffrey Childs, Lisa H. Gren, Anne Randall, Laura M. Dember, Denise do Vale Soares, Jerry Yee, Kausik Umanath, Naima Ogletree, Schwana Thaxton, Karen Camapana, Dayna Sheldon, Krista MacArthur, J. Brent Muhlestein, Nathan Allred, Brian Clements, Ritesh Dhar, Kent G. Meredith, Viet T. Le, Edward Miner, James L. Orford, Erik Riessen, Becca Ballantyne, Ben Chisum, Kevin B. Johnson, Dixie Peeler, Glenn M. Chertow, Manju Tamura, Tara I. Chang, Kevin F. Erickson, Jenny I. Shen, Randall S. Stafford, G. Zaharchuk, Margareth Del Cid, Michelle Dentinger, Jennifer Sabino, Rukmani Sahay, Ekaterina Telminova, Daniel E. Weiner, Mark J. Sarnak, Lily Chan, Amanda Civiletto, Alyson Heath, Amy Kantor, Priyanka Jain, Bethany Kirkpatrick, Andrew Well, Barry Yuen, Michel Choncol, Beverly Farmer, Heather R. Farmer, Carol Greenwald, Mikaela Malaczewski, James P. Lash, Anna Porter, Ana C. Ricardo, Robert T. Rosman, Janet Cohan, Nieves Lopez-Barrera, Daniel Meslar, Patricia Meslar, Margaret Conroy, Mark L. Unruh, Rachel Hess, Manisha Jhamb, Holly N. Thomas, Pam Fazio, Elle Klixbull, Melissa Komlos-Weimer, LeeAnne Mandich, Tina Vita, Robert Toto, Peter Van Buren, Julia Inrig, Martha Cruz, Tammy Lightfoot, Nancy Wang, Lori Webster, Kalani Rapheal, Barry M. Stults, Tahir Zaman, Debra L. Simmons, Tooran Lavasani, Rebecca Filipowicz, Guo Wei, Gracie Mary Miller, Jenice Harerra, Jeff Christensen, Ajay Giri, Xiaorui Chen, Natalie Anderton, Arianna Jensen, Julia Lewis, Anna Burgner, Jamie P. Dwyer, Gerald Schulman, Terri Herrud, Ewanda Leavell, Tiffany McCray, Edwina McNeil Simaan, Munmum Puodel, Malia Reed, Mohammed Sika, Delia Woods, Janice L. Zirkenback, Dominic S. Raj, Scott Cohen, Samir S. Patel, Manuel Velasquez, Roshni Bastian, Maria R. Wing, Akshay Roy-Chaudhury, Thomas A. Depner, Lorien Dalyrymple, George A. Kaysen, Susan M. Anderson, John Nord, Ajay Giri, Joachim H. Ix, Leonard Goldenstein, Cynthia M. Miracle, Nketi I Forbang, Maja Mircic, Brenda Thomas, Tiffany Tran, Anjay Rastogi, Mihae Kim, Mohamad Rashid, Bianca Lizarraga, Amy Hocza, Kristine Sarmosyan, Jason Norris, Tushar Sharma, Amanda Chjoy, Éric Bernard, Eleanore Cabrera, Christina Lopez, Susana Nunez, Joseph Riad, Suzanne Schweitzer, Siran Sirop, Sarah Thomas, Lauren Wada, Holly Kramer, Vinod Bansal, Corliss E. Taylor, Mark S. Segal, Karen Hall, Amir Kazory, Lesa R. Gilbert, Linda Owens, Danielle Poulton, Elaine Whidden, Jocelyn Wiggins, Caroline Blaum, Linda Nyquist, Lillian Min, Tanya R. Gure, Ruth Lewis, Jennifer Mawby, E Robinson, Suzanne Oparil, Cora E. Lewis, Virginia Bradley, David A. Calhoun, Stephen P. Glasser, Kim Jenkins, Tom Ramsey, Nauman Qureshi, Karen Ferguson, Sumrah Haider, Mandy James, Christy Jones, Kim Renfroe, April Seay, Carrie Weigart, Denyse Thornley‐Brown, Dana Rizik, Bari Cotoon, Meredith B. Fitz-Gerald, Tiffany Grimes, Carolyn J. Johnson, Sara Kennedy, Chanel Mason, Lesa Rosato-Burson, Robin Willingham, Eric Judd, Tonya L. Breaux-Shropshire, Felice Cook, Julia Medina, Lama Ghazi, Hemal Bhatt, James L. Lewis, Roman Brantley, John Brouilette, Jeffrey Glaze, Stephanie Hall, Nancy Hiott, David Tharpe, Spencer Boddy, Catherine E. Mack, Catherine Womack, Keiko Asao, Beate Griffin, Carol Hendrix, Karen Johnson, Lisa Jones, Chelsea Towers, Henry Punzi, Kathy Cassidy, Kristin Schumacher, Carmen Irizarry, Ilma Colon, Pedro Colon-Ortiz, Pedro Colón-Hernández, Orlando J. Carrasquillo-Navarro, Merari Carrasquillo, Nivea Vasquez, Miguel Sosa-Padilla, Alex Cintron-Pinero, Mayra Ayala, Olga Pacheco, Catalina Rivera, Irma Sotomayor-Gonzalez, Jamie Claudio, J. A. Lazaro, M.L. Arce, Lourdes Heres, Alba Pérez, Jose Tavarez-Valle, Ferlinda Arocho, Mercedes Torres, Melvaliz Vazquez, Gerard P. Aurigemma, Rebecca Takis-Smith, Julie Andrieni, Noelle Bodkin, Kiran Chaudhary, Paula Hu, John B. Kostis, Nora M. Cosgrove, Denise Bankowski, Monica Boleyn, Laurie Casazza, Victoria Giresi, Tosha Patel, Erin Squindo, Yan Yan Wu, Zeb Henson, Marion R. Wofford, Jessica Lowery, Deborah S. Minor, Kimberley Harkins, Alexander P. Auchus, Michael F. Flessner, Cathy Adair, Jordan Asher, Debbie Loope, Rita Cobb, Reiner Venegas, Thomas Bigger, Natalie A. Bello, Shunichi Homma, Daniel Donovan, Carlos Lopez-Jimenez, Amilcar Tirado, Asqual Gataneh, Rocky Tang, Sabrina Durant, Matthew J. Maurer, Sergio Teruya, Stephen Helmke, J Cuevas Alvarez, Ruth Campbell, Roberto Pisoni, Rachel L. Sturdivant, Deborah Brooks, Caroline Counts, Vickie Hunt, Lori Spillers, Donald Brautigam, Timothy Kitchen, Timothy Gorman, J. Sayers, Sarah Button, June Chiarot, Rosemary Fischer, Melissa Lyon, Maria Resnick, Nicole Hodges, Jennifer Ferreira, William C. Cushman, Barry M. Wall, Linda O. Nichols, Robert Burns, Jennifer Martindale‐Adams, Dan R. Berlowitz, Elizabeth A. Clark, Sandy Walsh, Terry Geraci, Carol Ann Huff, Linda K. Shaw, Karen S. Servilla, Darlene Vigil, Terry Barrett, Mary Ellen Sweeney, Rebecca J. Johnson, Susan McConnell, Khadijeh Shahid Salles, Francoise Watson, Cheryl Schenk, Laura Whittington, Maxine Maher, Jonathan Williams, Stephen L. Swartz, Paul R. Conlin, George Alexis, Rebecca P. Lamkin, Patti Underwood, Helen Gomes, Clive Rosendorff, Stephen Atlas, Saadat Khan, Waddy Gonzalez, Samih Barcham, Lawrence Kwon, Matar Matar, Anwar Adhami, Jan Basile, Joseph John, Deborah Ham, Hadi Baig, Mohammed Saklayen, Jason Yap, Helen Neff, Carol Miller, Ling Zheng-Phelan, Saib Gappy, Shiva Rau, Arathi Raman, Vicki Berchou, E. Jones, Erin Olgren, Cynthia Marbury, Michael Yudd, Sithiporn Sastrasinh, Jennine Michaud, Jessica Fiore, Marianne Kutza, Ronald I. Shorr, Rattana Mount, Helen Dunn, Susan Stinson, Jessica Hunter, Addison A. Taylor, Jeffery Bates, Catherine Anderson, Kent A. Kirchner, Jodi Stubbs, Ardell Hinton, Anita Spencer, Santosh Sharma, Thomas Wiegmann, Smita Mehta, Michelle W. Krause, Kate Dishongh, RICHARD H. CHILDRESS, Geeta Gyamlani, Atossa Niakan, Cathy Thompson, Janelle Moody, Carolyn Gresham, Jeff Whittle, Gary P. Barnas, Dawn F. Wolfgram, Heidi Cortese, Jonette Johnson, Christianne L. Roumie, Adriana M. Hung, Jennifer Wharton, Kurt J. Niesner, Lois Katz, Elizabeth Richardson, George Brock, Joanne Holland, Troy E. Dixon, Athena Zias, Christine Spiller, Penelope Baker, James V. Felicetta, Shakaib U. Rehman, Kelli Bingham, Suzanne Watnick, David Cohen, Jessica Weiss, Tera Johnston, Stephen J. Giddings, Hala Yamout, Andrew J. Klein, Caroline Rowe, Kristin Vargo, Kristi Waidmann, Vasilios Papademetriou, Jean Pierre Elkhoury, Barbara Gregory, Susan Amodeo, Mary Bloom, Dalia Goldfarb-Waysman, Richard M. Treger, Mehran Kashefi, Christina Huang, Karen Knibloe, Areef Ishani, Yelena Slinin, Christine M. Olney, Jacqueline Rust, Paolo Fanti, Christopher Dyer, Shweta Bansal, Monica Dunnam, Lih-Lan Hu, Perla Zarate-Abbott · 发表于：JAMA Neurology · 年份：2021 · DOI：10.1001/jamaneurol.2021.0178 · 被引用次数：74 · 研究领域：Dementia and Cognitive Impairment Research、Alzheimer's disease research and treatments、Neurological Disease Mechanisms and Treatments

Importance: Meta-analyses of randomized clinical trials have indicated that improved hypertension control reduces the risk for cognitive impairment and dementia. However, it is unclear to what extent pathways reflective of Alzheimer disease (AD) pathology are affected by hypertension control. Objective: To evaluate the association of intensive blood pressure control on AD-related brain biomarkers. Design, Setting, and Participants: This is a substudy of the Systolic Blood Pressure Intervention Trial (SPRINT MIND), a multicenter randomized clinical trial that compared the efficacy of 2 different blood pressure-lowering strategies. Potential participants (n = 1267) 50 years or older with hypertension and without a history of diabetes or stroke were approached for a brain magnetic resonance imaging (MRI) study. Of these, 205 participants were deemed ineligible and 269 did not agree to participate; 673 and 454 participants completed brain MRI at baseline and at 4-year follow-up, respectively; the final follow-up date was July 1, 2016. Analysis began September 2019 and ended November 2020. Interventions: Participants were randomized to either a systolic blood pressure goal of less than 120 mm Hg (intensive treatment: n = 356) or less than 140 mm Hg (standard treatment: n = 317). Main Outcomes and Measures: Changes in hippocampal volume, measures of AD regional atrophy, posterior cingulate cerebral blood flow, and mean fractional anisotropy in the cingulum bundle. Results: Among 67...