Dynamic PET/CT Imaging of 68Ga-FAPI-04 in Chinese Subjects

作者：Shuai Wang, Xin Zhou, Xiaoxia Xu, Jin Ding, Teli Liu, Jinquan Jiang, Nan Li, Hua Zhu, Zhi Yang · 发表于：Frontiers in Oncology · 年份：2021 · DOI：10.3389/fonc.2021.651005 · 被引用次数：42 · 研究领域：Peptidase Inhibition and Analysis、Protease and Inhibitor Mechanisms、Radiopharmaceutical Chemistry and Applications

This study aims to further explore dynamic 68 Ga-FAPI-04 PET/CT imaging of healthy Chinese subjects and lung cancer patients. Moreover, the variability of 68 Ga-FAPI-04 uptake in normal organs was measured to provide a basis for analyzing its biological distribution, interpreting auxiliary images, determining the reliability of image quantification, and monitoring treatment. Six patients (3 subjects without tumors and 3 lung cancer patients) separately underwent 68 Ga-FAPI-04 and 2-[ 18 F]FDG PET/CT imaging within 1 week. The biodistribution and internal radiation dosimetry were reported and compared with data previously obtained from Caucasian patients. Moreover, the mean SUV (standardized uptake value) was normalized to body mass or to lean body mass (SUL), and the coefficients of variation (CVs) were calculated and compared for each volume of interest. The average whole-body effective dose was calculated to be 1.27E-02 mSv/MBq, which was comparable with previously reported results of 68 Ga-FAPI-04 probes. Furthermore, the SUVmean was slightly higher than the SULmean in most organs; however, the CV of the SULmean for most organs was higher than that of the SUVmean at later time points. In the liver, the CV of the SUVmean was lower (12.7%) than that of the SULmean and was similar to the CV for corresponding 2-[ 18 F]FDG PET/CT value (11.8%). In addition, 68 Ga-FAPI-04 PET/CT showed good efficacy for diagnosing lung cancer patients in this study. A comparison of the radiation...