LPS-induced mitochondrial DNA synthesis and release facilitate RAD50-dependent acute lung injury

作者：Xueqin Zhan, Rui Cui, Xinwei Geng, Jiaqian Li, Yunlian Zhou, Lulu He, Chao Cao, Chao Zhang, Zhimin Chen, Songmin Ying · 发表于：Signal Transduction and Targeted Therapy · 年份：2021 · DOI：10.1038/s41392-021-00494-7 · 被引用次数：30 · 研究领域：Mitochondrial Function and Pathology、Inflammasome and immune disorders、interferon and immune responses

ATP-binding cassette (ABC)-ATPase (RAD50), together with meiotic recombination 11 homolog 1 (MRE11) subunits, to form MRE11–RAD50 complex, plays important roles in recognition of double-stranded DNA (dsDNA) and initiation of consequent inflammatory cascade 1 . Acute lung injury (ALI) and acute respiratory destress syndrome (ARDS) are systemic uncontrolled inflammation and life-threatening. However, the function of the DNA sensor in ALI/ARDS remains poorly defined. Here we investigated functions of RAD50 using mouse primary macrophages and conditionally RAD50 knockout mice in vitro and in a lipopolysaccharide (LPS)-induced lung injury model.