Subthalamic beta band suppression reflects effective neuromodulation in chronic recordings

作者：Lucia K. Feldmann, Wolf‐Julian Neumann, Patricia Krause, Roxanne Lofredi, Gerd‐Helge Schneider, Andrea A. Kühn · 发表于：European Journal of Neurology · 年份：2021 · DOI：10.1111/ene.14801 · 被引用次数：75 · 研究领域：Neurological disorders and treatments、Neuroscience and Neural Engineering、Transcranial Magnetic Stimulation Studies

BACKGROUND AND PURPOSE: Biomarkers for future adaptive deep brain stimulation still need evaluation in clinical routine. Here, we aimed to assess stimulation-induced modulation of beta-band activity and clinical symptoms in a Parkinson's disease patient during chronic neuronal sensing using a novel implantable pulse generator. METHODS: Subthalamic activity was recorded OFF and ON medication during a stepwise increase of stimulation amplitude. Off-line fast fourier transfom -based analysis of beta-band activity was correlated with motor performance rated from blinded videos. RESULTS: The stepwise increase of stimulation amplitude resulted in decreased beta oscillatory activity and improvement of bradykinesia. Mean low beta-band (13-20 Hz) activity correlated significantly with bradykinesia (ρ = 0.662, p < 0.01). CONCLUSIONS: Motor improvement is reflected in reduced subthalamic beta-band activity in Parkinson's disease, supporting beta activity as a reliable biomarker. The novel PERCEPT neurostimulator enables chronic neuronal sensing in clinical routine. Our findings pave the way for a personalized precision-medicine approach to neurostimulation.