A living WHO guideline on drugs to prevent covid-19

作者：François Lamontagne, Miriam Stegemann, Arnav Agarwal, Thomas Agoritsas, Reed Siemieniuk, Bram Rochwerg, Jessica J Bartoszko, Lisa Askie, Helen Macdonald, Muna Almaslamani, Wagdy Amin, André Ricardo Araújo da Silva, Fabián Alberto Jaimes Barragán, Frédérique Jacquerioz Bausch, Erlina Burhan, Maurizio Cecconi, Binila Chacko, Duncan Chanda, Vu Quoc Dat, Bin Du, Heike Geduld, Patrick O. Gee, Muhammad Mohsin Haider, Nerina Harley, Madiha Hashimi, Fyezah Jehan, David S.C. Hui, Beverley J. Hunt, Mohamed Ismail, S. K. Kabra, Seema Kanda, Letícia Kawano-Dourado, Yae‐Jean Kim, Niranjan Kissoon, Sanjeev Krishna, Arthur Kwizera, Thiago Lisboa, Yee‐Sin Leo, Imelda Mahaka, Hela Manai, Giovanni Battista Migliori, G Miño, Emmanuel Nsutebu, N. Pshenichnaya, Nida Qadir, Shalini Sri Ranganathan, Saniya Sabzwari, Rohit Sarin, Manu Shankar‐Hari, Michael Sharland, Yinzhong Shen, João Paulo Souza, Tshokey Tshokey, Sebastián Ugarte, Tim Uyeki, Sridhar Venkatapuram, Ablo Prudence Wachinou, Ananda Wijewickrama, Dubula Vuyiseka, Jacobus Preller, Romina Brignardello‐Petersen, Elena Kum, Anila Qasim, Dena Zeraatkar, Andrew Owen, Gordon Guyatt, Lyubov Lytvyn, Michael Jacobs, Per Olav Vandvik, Janet Dı́az · 发表于：BMJ · 年份：2021 · DOI：10.1136/bmj.n526 · 被引用次数：151 · 研究领域：COVID-19 Clinical Research Studies、Meta-analysis and systematic reviews、Health Policy Implementation Science

CLINICAL QUESTION: What is the role of drugs in preventing covid-19? WHY DOES THIS MATTER?: There is widespread interest in whether drug interventions can be used for the prevention of covid-19, but there is uncertainty about which drugs, if any, are effective. The first version of this living guideline focuses on the evidence for hydroxychloroquine. Subsequent updates will cover other drugs being investigated for their role in the prevention of covid-19. RECOMMENDATION: The guideline development panel made a strong recommendation against the use of hydroxychloroquine for individuals who do not have covid-19 (high certainty). HOW THIS GUIDELINE WAS CREATED: This living guideline is from the World Health Organization (WHO) and provides up to date covid-19 guidance to inform policy and practice worldwide. Magic Evidence Ecosystem Foundation (MAGIC) provided methodological support. A living systematic review with network analysis informed the recommendations. An international guideline development panel of content experts, clinicians, patients, an ethicist and methodologists produced recommendations following standards for trustworthy guideline development using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. UNDERSTANDING THE NEW RECOMMENDATION: The linked systematic review and network meta-analysis (6 trials and 6059 participants) found that hydroxychloroquine had a small or no effect on mortality and admission to hospital (high certaint...