Associations of Fish Consumption With Risk of Cardiovascular Disease and Mortality Among Individuals With or Without Vascular Disease From 58 Countries

作者：Deepa Mohan, Andrew Mente, Mahshid Dehghan, Sumathy Rangarajan, Martin O’Donnell, Weihong Hu, Gilles R. Dagenais, Andreas Wielgosz, Scott A. Lear, Wei Li, Rafael Díaz, Álvaro Avezum, Patricio López‐Jaramillo, Fernando Laņas, Sumathi Swaminathan, Manmeet Kaur, K. Vijayakumar, Viswanathan Mohan, Rajeev Gupta, Andrzej Szuba, Romaina Iqbal, Rita Yusuf, Noushin Mohammadifard, Rasha Khatib, Khalid Yusoff, Sadi Güleç, Annika Rosengren, Afzalhussein Yusufali, Edelweiss Wentzel‐Viljoen, Jephat Chifamba, Antonio Dans, Khalid F. AlHabib, Karen Yeates, Koon Teo, Hertzel C. Gerstein, Salim Yusuf, PURE, ONTARGET, TRANSCEND, and ORIGIN investigators · 发表于：JAMA Internal Medicine · 年份：2021 · DOI：10.1001/jamainternmed.2021.0036 · 被引用次数：147 · 研究领域：Fatty Acid Research and Health、Nutritional Studies and Diet、Sodium Intake and Health

Importance: Cohort studies report inconsistent associations between fish consumption, a major source of long-chain ω-3 fatty acids, and risk of cardiovascular disease (CVD) and mortality. Whether the associations vary between those with and those without vascular disease is unknown. Objective: To examine whether the associations of fish consumption with risk of CVD or of mortality differ between individuals with and individuals without vascular disease. Design, Setting, and Participants: This pooled analysis of individual participant data involved 191 558 individuals from 4 cohort studies-147 645 individuals (139 827 without CVD and 7818 with CVD) from 21 countries in the Prospective Urban Rural Epidemiology (PURE) study and 43 413 patients with vascular disease in 3 prospective studies from 40 countries. Adjusted hazard ratios (HRs) were calculated by multilevel Cox regression separately within each study and then pooled using random-effects meta-analysis. This analysis was conducted from January to June 2020. Exposures: Fish consumption was recorded using validated food frequency questionnaires. In 1 of the cohorts with vascular disease, a separate qualitative food frequency questionnaire was used to assess intake of individual types of fish. Main Outcomes and Measures: Mortality and major CVD events (including myocardial infarction, stroke, congestive heart failure, or sudden death). Results: Overall, 191 558 participants with a mean (SD) age of 54.1 (8.0) years (91 666 [4...