The significance of left ventricular ejection time in heart failure with reduced ejection fraction

作者：Alia Saed Alhakak, John R. Teerlink, JoAnn Lindenfeld, Michael Böhm, Giuseppe Rosano, Tor Biering‐Sørensen · 发表于：European Journal of Heart Failure · 年份：2021 · DOI：10.1002/ejhf.2125 · 被引用次数：84 · 研究领域：Cardiovascular Function and Risk Factors、Heart rate and cardiovascular health、Heart Failure Treatment and Management

Left ventricular ejection time (LVET) is defined as the time interval from aortic valve opening to aortic valve closure, and is the phase of systole during which the left ventricle ejects blood into the aorta. LVET has been used for several decades to assess left ventricular function and contractility. However, there is a recent interest in LVET as a measure of therapeutic action for novel drugs in patients with heart failure with reduced ejection fraction (HFrEF), since LVET is shortened in these patients. This review provides an overview of the available information on LVET including methods of measuring LVET, mechanistic understanding of LVET, association of LVET with outcomes, mechanisms behind shortened LVET in HFrEF and the potential implications of drugs that affect and normalize LVET.