Cleavable and tunable cysteine-specific arylation modification with aryl thioethers

作者：Jian Li, Junjie Deng, Zhibin Yin, Qi-Long Hu, Ge Yang, Zhendong Song, Ying Zhang, Albert S. C. Chan, Huilin Li, Xiao‐Feng Xiong · 发表于：Chemical Science · 年份：2021 · DOI：10.1039/d0sc06576e · 被引用次数：36 · 研究领域：Click Chemistry and Applications、Chemical Synthesis and Analysis、Peptidase Inhibition and Analysis

Ar approach was developed. Highly efficient and selective bioconjugation reactions can be carried out under mild and biocompatible conditions. A series of aryl groups bearing different bioconjugation handles, affinity or fluorescent tags are well tolerated. By adjusting the skeleton and steric hindrance of aryl thioethers slightly, the modified products showed a tunable profile for the regeneration of the native peptides.