Exercise training and reproductive outcomes in women with polycystic ovary syndrome: A pilot randomized controlled trial

作者：Jamie Laura Benham, Jane E. Booth, Bernard Corenblum, Steve Paul Doucette, Christine M. Friedenreich, Doreen M. Rabi, Ronald J. Sigal · 发表于：Clinical Endocrinology · 年份：2021 · DOI：10.1111/cen.14452 · 被引用次数：64 · 研究领域：Ovarian function and disorders、Hormonal and reproductive studies、Reproductive Biology and Fertility

Abstract Objective Exercise is recommended for polycystic ovary syndrome (PCOS), but the most effective exercise prescription is unclear. This trial compared effects of high‐intensity interval training (HIIT), continuous aerobic exercise training (CAET) and no‐exercise control on reproductive, anthropometric and cardiometabolic outcomes in PCOS. Design Pilot randomized controlled trial. Participants Previously inactive women aged 18–40 years with PCOS. Measurements Feasibility outcomes included recruitment, retention, adherence to exercise and daily ovulation prediction kit (OPK) testing. Preliminary efficacy outcomes included reproductive, anthropometric and cardiometabolic health markers. Results Forty‐seven women were randomized to no‐exercise control (n = 17), HIIT (n = 16), or CAET (n = 14). Forty (85%) participants completed the trial. Median exercise adherence was 68% (IQR 53%, 86%). Median daily OPK‐testing adherence in the first half of the intervention was 87% (IQR 61%, 97%) compared with 65% (IQR 0%, 96%) in the second half. Body mass index decreased significantly in CAET compared with control (−1.0 kg/m2, p = .01) and HIIT (−0.9 kg/m2, p = .04). Mean waist circumference decreased in all groups (−7.3 cm, −6.9 cm, −4.5 cm in HIIT, CAET and control) with no significant between‐group differences. Mean LDL‐C was significantly reduced for HIIT compared to CAET (−0.33 mmol/L, p = .03). HDL‐C increased in HIIT compared with control (0.18 mmol/L, p = .04). Conclusions Ther...