Case Report: Identification of SARS-CoV-2 in Cerebrospinal Fluid by Ultrahigh-Depth Sequencing in a Patient With Coronavirus Disease 2019 and Neurological Dysfunction

作者：Pan Xiang, Xinmin Xu, Xin Lü, Lili Gao, Huizhu Wang, Zhenpeng Li, Haofeng Xiong, Ruihong Li, Yanwen Xiong, Lin Pu, Tian Qin, Fangfang Jin, Hongyu Ren, Chuansheng Li, Jing Yang, Ming Zhang, Jie Gong, Xiaoping Chen, Han Zheng, Jianbo Tan, Yao Sun, Fei Zhao, Xuexin Hou, Yufeng Liu, Hebing Guo, Jingjing Hao, Biao Kan, Haijian Zhou, Yajie Wang, Jingyuan Liu · 发表于：Frontiers in Medicine · 年份：2021 · DOI：10.3389/fmed.2021.629828 · 被引用次数：17 · 研究领域：Long-Term Effects of COVID-19、Infectious Encephalopathies and Encephalitis、COVID-19 Clinical Research Studies

We reported that the complete genome sequence of SARS-Coronavirus-2 (SARS-CoV-2) was obtained from a cerebrospinal fluid (CSF) sample by ultrahigh-depth sequencing. Fourteen days after onset, seizures, maxillofacial convulsions, intractable hiccups and a significant increase in intracranial pressure developed in an adult coronavirus disease 2019 patient. The complete genome sequence of SARS-CoV-2 obtained from the cerebrospinal fluid indicates that SARS-CoV-2 can invade the central nervous system. In future, along with nervous system assessment, the pathogen genome detection and other indicators are needed for studying possible nervous system infection of SARS-CoV-2.