Antibacterial p -Terphenyl with a Rare 2,2′-Bithiazole Substructure and Related Compounds Isolated from the Marine-Derived Actinomycete Nocardiopsis sp. HDN154086

作者：Yimin Chang, Qian Che, Li Xing, Chuanteng Ma, Yaxin Han, Tianjiao Zhu, Blaine A. Pfeifer, Jixing Peng, Guojian Zhang, Dehai Li · 发表于：Journal of Natural Products · 年份：2021 · DOI：10.1021/acs.jnatprod.0c01296 · 被引用次数：19 · 研究领域：Microbial Natural Products and Biosynthesis、Catalytic C–H Functionalization Methods、Synthesis and Catalytic Reactions

Assisted by MS/MS-based molecular networking and X-ray diffraction analysis, five new p -terphenyl derivatives, namely, nocarterphenyls D–H ( 1 – 5 ), were obtained and characterized from the cultures of the marine sediment-derived actinomycete Nocardiopsis sp. HDN154086. The skeleton of nocarterphenyl D ( 1 ) was defined to possess a rare 2,2′-bithiazole scaffold, naturally occurring for the first time, and nocarterphenyls E–H ( 2 – 5 ) are p -terphenylquinones with unusual thioether linked fatty acid methyl ester substitutions. Compound 1 showed promising activity against multiple bacteria with MIC values ranging from 1.5 to 6.2 μM, and 2 exhibited notable antibacterial activity against MRSA which surpassed the positive control ciprofloxacin.