Review article: potassium‐competitive acid blockers for the treatment of acid‐related disorders

作者：Yousef Abdel‐Aziz, David C. Metz, Colin W. Howden · 发表于：Alimentary Pharmacology & Therapeutics · 年份：2021 · DOI：10.1111/apt.16295 · 被引用次数：113 · 研究领域：Gastroesophageal reflux and treatments、Helicobacter pylori-related gastroenterology studies、Potassium and Related Disorders

BACKGROUND: Potassium-competitive acid blockers (P-CABs) are a novel group of acid-suppressing medicines for the management of acid-related disorders. AIMS: To review published clinical pharmacology studies and clinical trials of P-CABs. METHODS: We conducted a comprehensive literature search including Medline (PubMed), EMBASE, Web of Science and the Cochrane Library from inception until November 2020, for studies of the clinical pharmacology of P-CABs and relevant clinical trials of those that are currently licensed or in development. RESULTS: Most publications concerned vonoprazan, which forms the bulk of this review. It is currently licensed in some Asian and South American countries and is being developed for North America. In clinically relevant doses, P-CABs have produced more rapid and profound suppression of intragastric acidity than proton pump inhibitors (PPIs). Vonoprazan was non-inferior to lansoprazole in healing erosive oesophagitis (2 randomised controlled trials [RCTs] in 1137 subjects) and superior in maintaining remission (1 RCT; 607 subjects). In 2 RCTs (1120 total subjects), both vonoprazan and tegoprazan were non-inferior to lansoprazole for healing peptic ulcers. Three RCTs and numerous non-randomised studies have compared vonoprazan-based and PPI-based regimens for Helicobacter pylori infection; vonoprazan-based triple or dual regimens have been highly effective. CONCLUSIONS: P-CABs have some potential advantages over PPIs. To date, most research has be...