Mesenchymal stem cells protect renal tubular cells via TSG-6 regulating macrophage function and phenotype switching

作者：Yu Zhao, Xiang-Yang Zhu, Turun Song, Lei Zhang, Alfonso Eirin, Sabena M. Conley, Hui Tang, Ishran M. Saadiq, Kyra L. Jordan, Amir Lerman, Lilach O. Lerman · 发表于：American Journal of Physiology-Renal Physiology · 年份：2021 · DOI：10.1152/ajprenal.00426.2020 · 被引用次数：35 · 研究领域：Tissue Engineering and Regenerative Medicine、Renal and Vascular Pathologies、Renal and related cancers

Tumor necrosis factor-α-induced gene/protein (TSG)-6 regulates the immunomodulatory properties of MSCs, but its ability to protect the ischemic kidney is unknown. In pigs with renal artery stenosis, we show that MSC delivery increased renal vein TSG-6, decreased kidney inflammatory macrophages, and improved renal function. In vitro, TSG-6 decreased inflammatory macrophages and tubular cell injury. Therefore, TSG-6 released from MSCs may decrease renal tubular cell injury, which is associated with regulating macrophage function and phenotype.