Nickel-Catalyzed Regioselective Hydroamination of Ynamides with Secondary Amines

作者：Xiao-Di Nie, Xiaoli Han, Jian‐Ting Sun, Chang‐Mei Si, Bang‐Guo Wei, Guo‐Qiang Lin · 发表于：The Journal of Organic Chemistry · 年份：2021 · DOI：10.1021/acs.joc.0c02807 · 被引用次数：13 · 研究领域：Catalytic Alkyne Reactions、Catalytic C–H Functionalization Methods、Catalytic Cross-Coupling Reactions

The first Ni(OTf) 2 -catalyzed hydroamination of ynamides 2 was developed by reacting with secondary amines ( 1 and 4 ). This protocol features excellent regioselectivity, a broad substrate scope of secondary aryl amines, and good functional group tolerance for ynamides. Using this method, a variety of substituted ethene-1,1-diamine compounds were prepared in moderate to excellent yields with high regioselectivities.