A novel predict factor that increases the success rate of methotrexate treatment in fallopian tube pregnancy

作者：Qin Lin, Nan Lin, Gongli Wang, Xuan Zheng, Renyi Hua · 发表于：Annals of Translational Medicine · 年份：2021 · DOI：10.21037/atm-20-7914 · 被引用次数：12 · 研究领域：Ectopic Pregnancy Diagnosis and Management、Gestational Trophoblastic Disease Studies、Appendicitis Diagnosis and Management

BACKGROUND: For stable fallopian tube pregnancy (FTP), methotrexate (MTX) therapy is reported to be as effective as laparoscopy. However, some cases would need further treatment, e.g., another dose of MTX or laparoscopy. This study is to investigate the potential factors during the treatment of FTP that may facilitate the prediction of a successful outcome of MTX therapy. METHODS: MTX prior to other treatment. Statistical analysis was performed to determine the correlation between clinical parameters and the success rate of MTX treatment. RESULTS: The success rate of single-dose MTX was 77.53%. The serum beta-human chorionic gonadotropin (β-hCG) level cut-off value was 452.64 IU/L, with a specificity of 76.7% and sensitivity of 43% [area under the receiver operating characteristic curve (AUC) 0.803; P<0.0001]. In addition, serum β-hCG levels and patient age correlated with the success rate of MTX treatment. CONCLUSIONS: Lower β-hCG levels led to successful MTX treatment for FTP, with a cutoff value of 452.64 IU/L. Younger patients were more sensitive to MTX treatment. These results may help clinicians when deciding the potential therapy for patients with tubal ectopic pregnancies.