Conjugated ynones in catalytic enantioselective reactions

作者：Linqing Wang, Haiyong Zhu, Tianyu Peng, Dongxu Yang · 发表于：Organic & Biomolecular Chemistry · 年份：2021 · DOI：10.1039/d0ob02521f · 被引用次数：40 · 研究领域：Catalytic Alkyne Reactions、Catalytic C–H Functionalization Methods、Asymmetric Synthesis and Catalysis

Conjugated ynones are easily accessible feedstock and the existence of an alkyne bond endows ynones with different attractive reactivities, thus making them unique substrates for catalytic asymmetric reactions. Their compatibility under organocatalytic, metal-catalyzed as well as cooperative catalytic conditions has resulted in numerous enantioselective transformations. Importantly, conjugated ynones can act as nucleophiles or electrophiles, and serve as easily accessed synthons for different cyclization pathways. This review summarizes the recent literature examples of the catalytic reactions of conjugated ynones and related compounds such as alkyne conjugated α-ketoesters, and classifies these reaction types alongside mechanistic insights whenever possible. We aim to trigger more intensive research in the future to render the asymmetric transformation of ynones as a common and reliable tool for asymmetric synthesis.